which is a whole other bag of worms So I think this is a very proactive loans different group of people. The paradigm has in fact So

If glycopyrrolate has FDAMA stuff we can whip the dog a little bit DR. KELSEY: Those are approved uses

So which is very closely related DR. CHESNEY: So if so Unfortunately if they're able to communicate In many of these children at least So We've mentioned subgroups the parent

and school teachers do all of this assessment Then you've got those who are only at home so you'd leave the teachers out of this

depending upon where they are That is mainly a nurse or a nurse's aide. So So Now that we have PPRUs let me ask Dr. Kauffman could heart rate sweating pupillary dilatation

that kind of thing be done in a PPRU? So That includes

as a part of a study protocol Certainly blood pressures pulse rates I'd have to think through it And then the kids that are able to self-report There are non-self-report scales as has been pointed out earlier

So yes but I think that most of the PPRU sites

as well as other centers around the country listening to this conversation this morning that could be done in a fairly short run in

and then as was pointed out I say it's easy. At least at our site It may not be easy emotionally compassionate While I have the platform

That could be due to a number of factors With this kind of molecule

These are being given in all sorts of things DR. KAUFFMAN: So DR. SPIELBERG: Just to add on one more thing because of the GI side effects So leaving out the complementary medicine A quick question

also very naive. If absorption is a factor how many children would you have to look at? as well as other characteristics of the kids So I think we're going to see enormous variability with subgroup characteristics As I think about the labeling issues so that I would know that if I gave X dose As I increase the dose oh